Alimen H. (1987). Evolution du climat et des civilisations depuis 40000 ans du nord au sud du Sahara occidental. (Premiéres conceptions confrontées aux données récentes). Bull. L’Assoc. Franç. L’Etude Quaternaire 4: 215-227.

Al Jabri AA. (2002). HLA and in vitro susceptibility to HIV infection. Molecular Immunology 38: 959-967.

Amiel JL. (1967). Study of the leukocyte phenotypes in Hodkin's disease. In: Curtoni ES, Mattiuz PL, Tosi RM, (eds.). Histocompatibility testing. Munksgaard. Copenhagen. Pp. 79-81.

Anjos S & Polychronakos C. (2004). Mechanisms of genetic susceptibility to type I diabetes: beyond HLA. Molecular Genetics and Metabolism 81: 187-195.

Armas J, Couto R, Santos M, Bettencourt B. (2004). HLA-A, -B, -Cw, -DQA1, -DQB1 and –DRB1 Alleles in a Population from the Azores. Human Immunology 65: 862-864.

Arnaiz-Villena A, Benmamar D, Alvarez M, Diaz-Campos N, Varela P, Gomez-Casado E, Martinez-Laso J. (1995). HLA allele and haplotype frequencies in Algerians. Relatedness to Spaniards and Basques. Hum. Immunol. 43: 259-268.

Arnaiz-Villena A, Martínez-Lazo J, Gómez-Casado E, Díaz-Campo N, Santos P, Martinho A, Breda-Coimbra H. (1997). Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes. Immunogenetics 47: 37-43.

Arnaiz-Villena A, Iliakis P, Gonzalez-Hevilla M, Longas J, Gomez-Casado E, Sfyridaki K, Trapaga J, Silvera-Redondo C, Matsouka C, Martinez-Laso J. (1999). The origin of Cretan populations as determined by characterization of HLA alleles. Tissue Antigens 53: 213-226.

Arnaiz-Villena A, Dimitroski K, Pacho A, Moscoso J, Gómez-Casado E, Silvera-Redondo C, Varela P, Blagoevska M, Zdravkovska V, Martínez-Laso J. (2001a). HLA genes in Macedonians and the sub-Saharan origin of Greeks. Tissue Antigens 57: 118-127.

Arnaiz-Villena A, Karin M, Bendikuze N, Gomez-Casado E, Moscoso J, Silvera C, Oguz FS, Sarper Diler A, Pacho A, Allende L, Guillen J, Martinez Laso L. (2001b). HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans. Tissue Antigens 57: 308-317.

Arnaiz-Villena A, Gomez-Casado E, Martinez-Laso J. (2002). Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective. Tissue Antigens 60: 111-121.

Ayed K, Ayed-Jendoubi S, Sfar I, Labonne MP, Gebuhrer L. (2004). HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. Tissue Antigens 64: 520-532.

Bach FH & Hirschhorn K. (1964). Lymphocyte interaction: a potential histocompatibility test in vitro. Science 142: 813-814.

Bain B, Vaz MR, Lowenstein L. (1964). The development of large immature mononuclear cells in mixed lymphocyte culture. Blood 23: 108-116.

Bannerman DA & Mary W. (1966). Birds of the Atlantic Islands. A History of the Birds of the Azores. (Vol. 3). Oliver & Boyd. Edinburgh.

Bender K, Bissbort S, Hiller C, Mayerová A, Wienker TF. (1983). On regional mapping of human chromossome 6. Review and own findings. Acta Anthropogenetica (New Delhi) 7: 85-105.

Benjamin R & Parham P. (1990). Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today. 11: 137-142.

Barcellos LF, Oksenberg JR, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL; Multiple Sclerosis Genetics Group. (2003). HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am. J. Hum. Genet. 72: 710 716.

Bera O, Cesaire R, Quelvennec E, Quillivic F, Chavigny V, Ribal C, Semana G. (2001). HLA class I and class II allele and haplotype diversity in Martinicans. Tissue Antigens 57: 200-207

Berah M & Dausset J. (1963). The use of the inverted microscope in leuco-agglutination. Vox Sang. 8: 371-375.

Bingulac-Popovic J, Figueroa F, Sato A, Talbot WS, Johnson SL, Gates M, Postlethwait JH, Klein J. (1997) Mapping of mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio. Immunogenetics 46: 129-134.

Birinci A, Bilgici A , Kuru O, Durupinar B. (2005). HLA-B27 polymorphism in Turkish patients with ankylosing spondylitis. Rheumatol Int. Jul 20: (Epub ahead of print).

Bjorkman PJ, Saper MA, Samraoui B, Bennet WS, Strominger JL, Wiley DC. (1987). Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329: 506-512.

Blanco-Gelaz MA, López-Vázques A, Garcia-Fernández S, Martínez-Borra J, González S, López-Larrea C. (2001). Genetic variability, molecular evolution, and geographic diversity of HLA-B27. Human Immunology 62: 1042-1050.

Bodmer JG, Marsh SGE, Albert E, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasasuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI. (1991). Nomenclature for factors of the HLA system, 1990. Tissue Antigens 37: 97–104.

Bodmer W. (1972). Evolutionary significance of the HLA system. Nature 237: 139–145.

Boehncke WH, Loeliger C, Kuehnl P, Kalbacher H, Bohm BO, Gall H. (1998). Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy. Clin Exp Allergy. 28: 434-41.

Borelli SD, Souza D, Freitas KFF, Botini FF, Melo FC, Bedendo J. (2004). Comparative study between serological and PCR-SSP methods to determine class II HLA molecules. Acta Scientiarum. Health Sciences Maringá 26: 337.

Braun J, Bollow M, Remlinger G, Eggens U, Rudwaleit M, Distler A, Sieper J. (1998). Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41: 58-67.

Brehm A, Pereira L, Bandelt HJ, Prata MJ, Amorim A. (2002). Mitochondrial portrait of the Cabo Verde archipelago: the Senegambian outpost of Atlantic slave trade. Ann. Hum. Genet. 66: 49-60.

Brehm A, Pereira L, Kivisild T, Amorim A. (2003). Mithocondrial portraits of the Madeira and Açores archipelagos witness different genetic pools of its settlers. Hum Genet 114: 77-86.

Brown JH, Jardetsky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC. (1993). Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364: 33-39.

Bruges-Armas J, Martinez-Laso J, Martins B, Allende L, Gomez-Casado E, Longas J, Varela P, Gonzalez-Granado M, Arnaiz-Villena A. (1999). HLA in Azores Arquipelago: possible presence of Mongoloid genes. Tissue Antigens 54: 349-359.

Bunce M, Barnardo M, Browning M, Morris P, Welsh K. (1995)
Phototyping: commprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46: 355-367.

Calin A. (2002). Définir l’évolution de la spondylarthrite ankylosante: d’où venons-nous, où en sommes-nous, où allons-nous ? Rev Rhum 69: 183-187.

Cao K, Hollenbach J, Shi X, Shi W, Chopek M, Fernández-Viña MA. (2001). Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Human Immunology 62: 1009-1030.

Cao K, Moormann AM, Lyke KE, Masaberg C, Sumba OP, Doumbo OK, Koech D, Lancaster A, Nelson M, Meyer D, Single R, Hartzman RJ, Plowe CV, Kazura J, Mann DL, Sztein MB, Thomson G, Fernández-Vina MA. (2004). Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. Tissue Antigens 63: 293-325.

Carreira A. (1983). Migrações nas Ilhas de Cabo Verde. (2nd ed). Instituto Caboverdeano do Livro. Lisboa.
Chakraborty R. (1990). Mitochondrial DNA polymorphism reveals hidden heterogeneity within some Asian populations. Am. J. Hum. Genet. 47: 87- 94.

Chabas D, Taheri S, Renier C, Mignot E. (2003). The genetics of narcolepsy. Annu. Rev. Genomics Hum. Genet. 4: 459–483.

Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Ronningen KS, Begovich A, King MC, McWeeney S, Mack SJ, Erlich HA, Thomson G. (1999). Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups. Tissue Antigens 54: 533-542.

Chimge N, Tanaka H, Kashiwase K, Ayush D, Tokunaga K, Saji H, Akaza T, Batsuuri J, Juji T. (1997). HLA system in the population of Mongolia. Tissue Antigens 49: 477-484.

Cicciarelli JC. (2004). HLA typing immunogenetics and transplantation. Current Opinion in Organ Transplantation 9: 1-7.

Clayton J, Lonjou C, Whittle D. (1997). Allele and Haplotype frequencies for HLA loci in various ethnic groups. In: Charron D. (ed.). Genetic diversity of HLA. Functional and medical implications. EDK. Paris. Pp. 665-820.

Cope AP & Sonderstrup G. (1998). Evaluating candidate autoantigens in rheumatoid arthritis. Springer Semin Immunopathol. 20: 23–39.

Couto AR, Peixoto MJ, Garrett F, Laranjeira F, Cipriano T, Armas JB. (2003). Linkage disequilibrium between S65C HFE mutation and HLA A29-B44 haplotype in Terceira Island, Azores. Hum Immunol. 64: 625-628.

Couto AR, Gonzalez T, Spínola H, Santos MR, Gantes Mora M, Brehm A, Peixoto MJ, Garrett F, Bruges Armas J. (2004). HLA-B*2703 in Azorean Caucasoids. Genes Immun 5: 233.

Daniel WW. (1987). Biostatistics: a foundation for analysis in the health sciences. John Wiley & Sons. London.

Dard P, Schreiber Y, Excoffier L, Sanchez-Mazas A, Shi-Isaac X, Epelbouin A, Langaney A, Jeannet M. (1992). Polymorphism of HLA class I loci HLA-A, -B and -C in a Mandenka population from Eastern Senegal. C.R. Acad. Sci. Paris 314: 573-578.

Dausset J. (1958). Iso-leuco-anticorps. Acta Haematologica 20: 156-166.

Dempster A, Laird N, Rubin D. (1977). Maximum likelihood estimation from incomplete data via the EM algorithm. Journal of the Royal Statistical Society B 39:1–38.

Doherty PC & Zinkernagel RM. (1975). A biological role for the major histocompatibility antigens. Lancet 1: 1406-1409.

Donadi EA, Cássia M, Santos P, Nepom GT. (2000). HLA-DR and HLA-DQ typing: A comparative study using serology and restriction fragment length polymorphism (RFLP) analysis. Medicina Ribeirão Preto 33: 27.

Dupont B, (ed.). (1988). Immunobiology of HLA. Histocompatibility Testing 1987. Springer-Verlag. New York.

Dutour O, Vernet R, Aumassip G. (1988). Le peuplement pré historique du Sahara. In: Aumassip G. et al. (eds): Milieux, hommes et techniques du Sahara pré historique. Problémes actuels: L’Harmattan. Paris. Pp. 39-52.

Ejele OA & Nwauche CA. (2004). Determination of paternity disputes in the niger delta region of Nigeria. Niger Postgrad Med J. 11:187-189.

Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ. (1994). The genetics of psoriasis. Arch Dermatol 130: 216-224.

Ellis JM, Mack SJ, Leke RFG, Quakyi I, Johnson AH, Hurley CK. (2000). Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-B1403, *4016, *4703. Tissue Antigens 56: 291-302.

Ewens WJ. (1972). The sampling theory of selectively neutral alleles. Theor. Pop. Biol. 3: 87-112.

Excoffier L, Smouse PE, Quattro JM. (1992). Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. Genetics 131: 479-491.

Excoffier L & Slatkin M. (1995). Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol. 12: 921-927.

Farjadian S, Naruse T, Kawata H, Ghaderi A, Bahram S, Inoko H. (2004). Molecular analysis of HLA allele frequencies and haplotypes in Baloch of Iran compared with related populations of Pakistan. Tissue Antigens 64: 581-587.

Felsenstein J. (2004). PHYLIP (Phylogeny Inference Package) version 3.6. Distributed by the author. Department of Genome Sciences, University of Washington. Seattle.

Fernandes A & Brehm A. (2003). Y-chromosome STR haplotypes in the Azores Archipelago (Portugal). Forensic Sci. Int. 135: 239-242.

Fernandes AT, Brehm A, Alves C, Gusmão L, Amorim A. (2001). Genetic profile of the Madeira Archipelago population using the new Power Plex2 16 System Kit. Forensic Sci. Int. 3228: 1-3.

Fernandes AT, Velosa R, Jesus J, Carracedo A, Brehm A. (2003). Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms. Ann. Hum. Genet. 67: 340-347.

Ferraz AS, Saber LS, Voltarelli JC, Mytilineos J, Opelz G, Donadi EA. (2002). Comparative Study of HLA-DR Typing by Serology and Sequence-Specific Primer Analysis in a Genetically Highly Diverse Population of Kidney Transplant Recipients. Transplantation Proceedings 34: 463-465.

Frutuoso G. (1977). Saudades da Terra (written in 1580-1591). Livro IV, vol I. Edição Instituto Cultural de Ponta Delgada. Ponta Delgada.

Gao X, Lester S, Boettcher B, McCluskey J. (1997). Diversity of HLA genes in populations of Australia and the Pacific. In: Charron D (ed.). HLA Genetic Diversity of HLA. Functional and Medical Implication. Vol.I. Pp 298-306.

Garrigan D & Hedrick PW. (2003). Perspective: Detecting Adaptive Molecular Polymorphism: Lessons from the MHC. Evolution 57: 1707–1722.

Gatti E & Pierre P. (2003). Understanding the cell biology of antigen presentation: the dendritic cell contribution. Current Opinion in Cell Biology 15:468–473.

Gibert M, Balandraud N, Touinssi M, Mercier P, Roudier J, Reviron D. (2003). Functional Categorization of HLA-DRB1 Alleles in Rheumatoid Arthritis: The Protective Effect. Human Immunology 64, 930–935.

Godinho VM. (1965). Os descobrimentos e a economia mundial. (Vol. 1-2). Arcádia. Lisboa.

Gómez-Casado E, del Moral P, Martínez-Laso J, García-Gómez A, Allende L, Silvera-Redondo C, Longas J, González-Hevilla M, Kandil M, Zamora J, Arnaiz-Villena A. (2001). HLA genes in Arabic speaking Moroccans: close relatedness to Berbers and Iberians. Tissue Antigens 55: 239-249.

Gonçalves R, Jesus J, Fernandes AT, Brehm A. (2002). Genetic profile of a multi-ethnic population from Guiné-Bissau (west African coast) using the new PowerPlex 16 System kit. Forensic Science International 129: 78-80.

Gonçalves R, Rosa A, Freitas A, Fernandes A, Kivisild T, Villems R, Brehm A. (2003). Y-Chromosome lineages in Cabo Verde Islands witness the diverse geographic origin of its first male settlers. Hum. Gent. 113: 467-472.

Gonçalves R, Freitas A, Branco M, Rosa A, Fernandes AT, Zhivotovsky LA, Underhill PA, Kivisild T, Brehm A. (2005). Y-chromosome lineages from Portugal, Madeira and Azores record elements of Sephardim and Berber ancestry. Annals Human Genetics 69: 443-454.

González A, Brehm A, Pérez J, Maca-Meyer N, Flores C, Cabrera V. (2003). Motochondrial DNA affinities at the Atlantic fringe of Europe. American Journal of Physical Anthropology 120: 391-404.

Gonzalez S, Garcia-Fernandez S, Martinez-Borra J, Blanco-Gelaz MA, Rodrigo L, del Río JS, López-Vazquez A, Torre-Alonso JC, López-Larrea C. (2002). High Variability of HLA-B27 Alleles in Ankylosing Spondylitis and Related Spondyloarthropathies in the Population of Northern Spain. Human Immunology 63: 673–676.

Gorer PA. (1937). The genetic and antigenic basis of tumour transplantation. Journal of Pathology & Bacteriology 44: 691-697.

Grubic Z, Stingl K, Martinez N, Palfi B, Brkljacic-Kerhin V, Kastelan A. (2004). STR and HLA analysis in paternity testing. International Congress Series 1261: 535– 537.

Guill JH. (1993). A History of the Azores Islands. Golden Shield International. Tulare. Pp 124-127.

Hardy GH. (1908). Mendelian proportions in a mixed population. Science 28: 49-50.

Healey D, Ozegbe P, Arden S, Chandler P, Hutton J, Cooke A. (1995). In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest. 95: 2979-85.

Hedrick PW & Thomson G. (1983). Evidence for balancing selection at HLA. Genetics 104: 449-456.

Hedrick PW & Thomson G. (1988). Maternal-fetal interactions and the maintenance of HLA polymorphism. Genetics 119: 205-212.

Hedrick PW, Whittam TS, Parham P. (1991). Heterozygosity at individual amino acid sites: Extremely high levels for HLA-A and HLA-B genes. Proc Natl Acad Sci USA 88: 5897-5901.

Hedrick PW. (1999). Balancing selection and MHC. Genetica 104: 207-14.

Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael AJ, Greenwood BM. (1991). Common west African HLA antigens are associated with protection from severe malaria. Nature 352: 595-600.

Hillert J & Olerup O. (1993). HLA and MS. Neurology 43: 2426 2427.

Howell WM, Evans PR, Spellerberg MB, Wilson PJ, Smith JL. (1989). A comparison of serological, cellular and DNA-RFLP methods for HLA matching in the selection of related bone marrow donors. Bone Marrow Transplant. 4: 63-68.

Hughes AL & Nei M. (1988). Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335: 167-170.

Huttley GA, Smith MW, Carrington M, O’Brien SJ. (1999). A scan for linkage disequilibrium across the human genome. Genetics 152: 1711-1722.

Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T. (1992). Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In: Tsuji K, Aizaea M, Sasazuki T (eds.). HLA 1991. (Vol. 1). Oxford University Press. Oxford. Pp. 1065-220.

Ivanova M, Spassova P, Michailova A, Naumova E. (2001). Distributions of HLA class I alleles and haplotypes in Bulgarians-contribution to understanding the origin of the population. Tissue Antigens 57: 208-215.

Jaini R, Kaur G, Mehra NK. (2002). Heterogeneity of HLA-DRB1*04 and its associated haplotypes in the north indian population. Human Immunology 63: 24-29.

Jakobsen IB, Gao X, Easteal S, Chelvanayagam G. (1998). Correlating sequence variation with HLA-A allelic families: Implications for T cell receptor binding specificities. Immunology and Cell Biology 76: 135-142.

Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, Ishibashi T. (1996). Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci USA 93: 9096-9101.

Kasahara M, Nakaya J, Satta Y, Takahata N. (1997). Chromosomal duplication and the emergence of the adaptive immune system. Trends in Genetics 13: 90-92.

Katz JD, Benoist C, Mathis D. (1995). T helper cell subsets in insulin-dependent diabetes. Science 268:1185-1188.

Khan MA. (2000). HLA-B27 polymorphism and association with disease. J Rheumatol 27: 1110-1114.

Kippax PJ, Sheldon S, Dyer PA. (1985). A simple and rapid method for the detection of lymphocytotoxic antibodies using cell panels frozen on Terasaki plates. Tissue Antigens 26:318-322.

Klein J & Sato A. (2000). The HLA system. First of two parts. New England Journal of Medicine 343: 702-709.

Kurz B, Steiert I, Heuchert G, Müller CA. (1999). New high resolution typing strategy for HLA-A locus alleles based on dye terminator sequencing of haplotypic group-specific PCR-amplicons of exon 2 and exon 3. Tissue Antigens 53: 81-96.

Larsen CE & Alper CA. (2004). The genetics of HLA-associated disease. Current Opinion in Immunology 16: 660–667.

Layrisse Z, Guedez Y, Domínguez E, Paz N, Montagnani S, Matos M, Herrerra F, Ogando V, Balbas O, Rodrigues-Larralde A. (2001). Extended HLA haplotypes in a Carib Amerindian population: The Yucpa of the Perija Range. Hum. Immunol. 62: 992-1000.

Le Bouteiller P. (1997). HLA-G: on the track of immunological functions. Eur J Immunogenet 24:397-408.

Leffell MS, Fallin MD, Hildebrand WH, Cavett JW, Iglehart BA, Zachary AA. (2004). HLA alleles an haplotypes among the Lakota Sioux: Report of the ASHI minority worshops, part III. Hum. Immunol. 65: 78-89.

Li N & Stephens M. (2003). Modelling Linkage Disequilibrium and Identifying Recombination Hotspots Using Single-Nucleotide Polymorphism Data. Genetics 165: 2213-2233.

Luo M, Embree J, Ramdahin S, Ndinya-Achola J, Njenga S, Bwayo JB, Pan S, Mao X, Cheang M, Stuart T, Brunham RC, Plummer FA. (2002). HLA-A and HLA-B in Kenya, Africa: Allele frequencies and identification of HLA-B*1567 and HLA-B*4426. Tissue Antigens 59: 370-380.

Lyon E & Frank EL. (2001). Hereditary Hemochromatosis Since Discovery of the HFE Gene. Clinical Chemistry 47: 1147–1156.

Mack SJ, Bugawan TL, Moonsamy PV, Erlich JA, Trachtenberg EA, Paik YK, Begovich AB, Saha N, Beck HP, Stoneking M, Erlich HA. (2000). Evolution of Pacific/Asian populations inferred from HLA class II allele frequency distributions. Tissue Antigens 55: 383-400.

Malissen M, Malissen B, Jordan BR. (1982). Exon/intron organization and complete nucleotide sequence of an HLA gene. Proc. Natl. Acad. Sci. U.S.A. 79: 893–897.

Marker-Hermann E & Hoehler T. (1998). Pathogenesis of human leukocyte antigen B27-positive arthritis: information from clinical materials. Rheum Dis Clin North Am 24: 865-881.

Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Geraghty DE, Hansen JA, Mach B, Mayr WR, Parham P, Petersdorf EW, Sasazuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI. (2002). Nomenclature for factors of the HLA system, 2002. Tissue Antigens 60: 407–464.

Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Geraghty DE, Hansen JA, Hurley CK, Mach B, Mayr WR, Parham P, Petersdorf EW, Sasazuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI, Trowsdale J. (2005). Nomenclature for factors of the HLA system, 2004. Tissue Antigens 65: 301–369.

Martinez-Laso J, De Juan D, Martinez-Quiles N, Gomez-Casado E, Cuarado E, Arnaiz-Villena A. (1995). The contribution of the HLA-A, -B, -C and -DR, -DQ DNA typing to the study of the origin of Spaniards and Basques. Tissue Antigens 45: 237-245.

Martinho A, Simões O, Santos P, Ferreira R, Paiva A, Mateus R, Ferreira A, Gomes J, Brêda-Coimbra H. (1995). Analysis of HLA-DR, DQA1 and DQB1 polymorphism in a Portuguese population. Eur. J. Immunogenetics 22: 125.

McFarlin DE & McFarland HF. (1982a). Multiple sclerosis (first of two parts). N. Engl. J. Med. 307: 1183 1188.

McFarlin DE & McFarland HF. (1982b). Multiple sclerosis (second of two parts). N. Engl. J. Med. 307: 1246 1251.

McGinnis MD, Conrad MP, Bouwens AGM, Tilanus MGJ, Kronick MN. (1995) Automated solid-phase sequencing of DRB region genes using T7 sequencing chemistry and dye-labeled primers. Tissue Antigens 46: 173-179.

Mendonça L. (1996). História dos Açores. Visão Geral (séc.XV-XIX). Edição Centro de Apoio Tecnológico à Educação. Ponta Delgada.

MHC sequencing consortium. (1999). Complete sequence and gene map of a human major histocompatibility complex. Nature 401:921-923.

Mickelson E, Smith A, McKinney S, Anderson G, Hansen JA. (1993). A comparative study of HLA-DRB1 typing by standard serology and hybridization of non-radioactive sequence-specific oligonucleotide probes to PCR-amplified DNA. Tissue Antigens 41:86-93.

Middleton D, Manavalan JS, Fernandez-Vina MA, (eds.). (2004). Human Immunology 65: 855-1272.

Middleton D. (2000). PCR-SSOP Class I and Class II (DRB1). In: Land GA, Strothman RM, Hahn AB. (eds.). ASHI Laboratory Manual, 4th edition. American Society for Histocompatibility and Immunogenetics. Lenexa.

Middleton D, Williams F, Hamill MA, Meenagh A. (2000). Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy. Hum. Imm. 61: 1285-1297.

Middleton D & Williams F. (1997). A History of DNA Typing for HLA. In: HLA 1997. Terasaki and Gjertson (Eds.). UCLA Tyssue Typing Laboratory. Los Angeles. California. Pp 61.

Middleton D, Menchaca E, Rood H, Komerofsky H. (2003). New allele frequency database: http://www.allelefrequencies.net. Tissue Antigens 61: 403-407.

Miller MM, Goto R, Bernot A, Zoorob R, Auffray C, Bumstead N, Briles WE. (1994). Two Mhc class I and two Mhc class II genes map to the chicken Rfp-Y system outside the B complex. Proc Natl Acad Sci USA 91:4397-4401.

Mitsunaga S, Tokunaga K, Kashiwase K, Akaza T, Tadokoro K, Juji T. (1998). A nested PCR-RFLP method for high-resolution typing of HLA-A alleles. Eur J Immunogenet. 25: 15-27.

Mizuki N, Kimura M. (1996). Gene structure of the human MHC region. Nippon Rinsho 54:1705-17.

Modiano D, Luoni G, Petrarca V, Sodiomon Sirima B, De Luca M, Simpore J, Coluzzi M, Bodmer JG, Modiano G. (2001). HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations. Tissue Antigens 57: 128-137.

Moghaddam PH, de Knijff P, Schipper RF, Kazemi M, Lambooij SLE, van der Meer R, Naipal A, Pesonen N, van der Slik A, Gliphart MJ. (1998). Selective co-evolution of the D6STNFa microsatellite region with HLA class I and II loci. Tissue Antigens 52: 213-219.

Monod T. (1991). Spectacles de la Terre. The Azores. Selection du Reader’s Digest. Paris.

Moore BS, Ploeger NA, DeGoey SR. (1997). HLA Antibody Screening: Comparison of a Solid Phase Enzyme-Linked Immunoassay with Antiglobulin-Augmented Lymphocytotoxicity. Transplantation 64: 1617-1620.

Moreira JM. (1964). Os Fulas da Guiné Portuguesa na panorâmica geral do mundo Fula. Boletim Cultural a Guiné Portuguesa 19: 417-432.

Morison SE. (1965). Portuguese Voyages to America in the Fifteenth Century. Octagon Books. New York.

Mullis KB & Faloona F. (1987). Specific synthesis of DNA in vitro via a polymerase catalysed chain reaction. Meth Enzymol 155: 335-350.

Muro M, Marín L, Torío A, Moya-Quiles M, Minguela A, Rosique-Roman J, Sanchis M, Garcia-Calatayud M, Garcia-Alonso A, lvarz-López M. (2001). HLA polymorphism in the Murcia population (Spain): in the cradle of the archeological Iberians. Hum. Immunology 62: 910-921.

Mytilineos J, Scherer S, Opelz G. (1990). Comparison of RFLP-DR beta and serological HLA-DR typing in 1500 individuals. Transplantation 50: 870-873.

Nei M & Gojobori T. (1986). Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Molecular Biology and Evolution 3: 418-426.

Nei M. (1987). Molecular Evolutionary Genetics. Columbia University Press. New York. Pp180.

Olerup O & Zetterquist H. (1992). HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 39: 225-235.

Olerup O & Zetterquist H. (1993). DR “low-resolution” PCR-SSP typing – a correction and an up-date. Tissue Antigens 41: 55-56.

Ota M, Seki T, Fukushima H, Tsuji K, Inoko H. (1992). HLA-DRB1 genotyping by modified PCR-RFLP method combined with group-specific primers. Tissue Antigens 39:187-202.

Page RDM. (1996). TREEVIEW: An application to display phylogenetic trees on personal computers. Computer Applications in the Biosciences 12: 357-358.

Parham P, Lomen CE, Lawlor DA, Ways JP, Holmes N, Coppin HL, Salter RD, Wan AM, Ennis PD. (1988). Nature of polymorphism in HLA-A, -B, and -C molecules. Proc Natl Acad Sci USA 85: 4005-4009.

Pereira ECN. (1989). Ilhas de Zarco (4th edition, Vol. II). Câmara Municipal Funchal. Funchal.

Pereira L, Prata MJ, Amorim A. (2000). Diversity of mtDNA lineages in Portugal: not a genetic edge of European variation. Ann. Hum. Genet. 64, 491-506.

Piancatelli D, Canossi A, Aureli A, Oumhani K, Del Beato T, Di Rocco M, Liberatore G, Tessitore A, Witter K, El Aouad R, Adorno D. (2004). Human leukocyte antigen-A, -B, and –Cw polymorphism in a Berber population from North Morocco using sequence-based typing. Tissue Antigens 63: 158-172.

Piazza A & Lonjou C. (1997). HLA in Europe and other Mediterranean countries. In: Charron D. (ed.). Genetic diversity of HLA. Functional and medical implications. (Vol. I). EDK. Paris. Pp. 374-386.

Pimtanothai N, Hurley CK, Leke R, Klitz W, Johnson AH. (2001). HLA-DR and –DQ polymorphism in Cameroon. Tissue Antigens 58: 1-8.

Pinto F, González AM, Hernández M, Larruga J, Cabrera V. (1996). Genetic relationship between the Canary Islanders and their African and Spanish ancestros inferred from mtDNA sequences. Ann. Hum. Genet. 60: 321-330.

Pozzi S, Longo A, Ferrara GB. (1999). HLA-B locus sequence-based typing. Tissue Antigens 53: 275-281.

Ramos M & Lopez de Castro JA. (2002). HLA-B27 and the pathogenesis of spondyloarthritis. Tissue Antigens 60: 191-205.

Rando JC, Pinto F, González AM, Hernández M, Larruga JM, Cabrera VM, Bandelt HJ. (1998). Mitochondrial DNA analysis of North-west African populations reveals genetic exchanges with European, Near-Eastern, and Sub-Saharan populations. Ann. Hum. Genet. 62: 531-550.

Rendine S, Borelli I, Barbanti M, Sacchi N, Roggero S, Curtoni ES. (1998). HLA polymorphisms in Italian bone marrow donors: a regional analysis. Tissue Antigens 52: 135-146.

Renquin J, Sanchez-Mazas A, Halle L, Rivalland S, Jaeger G, Mbayo K, Bianchi F, Kaplan C. (2001). HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity. Tissue Antigens 58: 211-222.

Reveille JD, Ball EJ, Khan MA. (2001). HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol. 13: 265-272.

Riley E & Olerup O. (1992). HLA polymorphism and evolution. Immunol Today 13: 333-5.

Rogers FM. (1979). Atlantic Islanders of the Azores and Madeira. Christopher House. North Quincy.

Rohlf FJ. (1997). NTSYS-PC, Numerical Taxonomy and Multivariate Analysis System. V. 2.0. Exeter Software, Applied Biostatistics, Inc, Setauket.

Ronningen KS, Spurkland A, Markussen G, Iwe T, Vartdal F, Thorsby E. (1990). Distribution of HLA class II alleles among Norwegian Caucasians. Hum. Immunol. 29: 275-281.

Rosa A, Brehm A, Kivisild T, Metspalu E, Villems R. (2004). MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region. Ann. Hum. Gen. 68: 340-352.

Russell-Wood AJ. (1998). The Portuguese empire, 1415-1808. A world on the move. Johns Hopkins Univ. Press. Baltimore, London.

Saiki R, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N. (1985). Enzymatic amplification of b-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230: 1350-1354.

Sambrook J, Fritsch EF, Maniatis T. (1989). Molecular Cloning- A Laboratory Manual (2nd edition, Vol. I, II, III). EUA: Cold Spring Harbor Laboratory Press.

Sanchez-Mazas A, Djoulah S, Busson M, Le Monnier de Gouville I, Poirier JC, Dehay C, Charron D, Excoffier L, Schneider S, Langaney A, Dausset J, Hors J. (2000). A linkage disequilibrium map of the MHC region based on the analysis of 14 loci haplotypes in 50 French families. Eur J Hum Genet 8: 33-41.

Sanchez-Mazas A. (2001). African diversity from the HLA point of view: influence of genetic drift, geography, linguistics, and natural selection. Hum.
Immunology 62: 937-948.

Sánchez-Velasco P, Escribano de Diego J, Paz-Miguel JE, Ocejo-Vinyals G Leyva-Cobián F. (1999). HLA-DR, DQ nucleotide sequence polymorphisms in the Pasiegos (Pas valleys, Northern Spain) and comparison of the allelic and haplotypic frequencies with those of other European populations. Tissue Antigens 53: 65-73.

Sanchez-Velasco P, Gomez-Casado E, Martinez-Lazo J, Moscoso J, Zamora J, Lowy E, Silvera C, Cemborain A, Leyva-Cobián F, Arnaiz-Villena A. (2003). HLA alleles in isolated populations from North Spain: Origin of the Basques and ancient Iberians. Tissue Antigens 61: 384-392.

Santos P, Fonseca AM, Martinho A, Ferreira RV, Simões O, Mateus MR, Gomes J, Silva JM, Freitas A, Paiva A, Brêda-Coimbra H. (1997). HLA-A, B, C polymorphism in Portuguese Caucasoids by ARMS-PCR SSP based typing. Eur. J. Immunogenetics 24: 15.

Schipper RF, D’Amaro J, Rood JJV, Oudshoorn M. (1996). The probability of finding a haplotypically identical unrelated bone marrow donor. In: Anonymous Genetic Diversity of HLA: Functional and Medical Implications. 2. Sèvres: EDK.

Schipper RF, D'Amaro J, de Lange P, Schreuder GM, van Rood JJ,Oudshoorn M. (1998). Validation of haplotype frequency estimation methods. Hum Immunol. 59: 518-523.

Schmidt D, Goronzy JJ, Weyand CM. (1996). CD4+, CD7-, CD28- T Cells Are Expanded in Rheumatoid Arthritis and Are Characterized by Autoreactivity. J Clin Invest. 97: 2027–2037.

Schneider S, Kueffer J M, Roessli D, Excoffier L. (2000). Arlequin v2.000: A software for population genetic data analysis. Genetics and Biometry Laboratory, University of Geneva. Geneva, Switzerland.

Scozzari R, Cruciani F, Pangrazio A, Santolamazza P, Vona G, Moral P, Latini V, Varesi L, Memmi MM, Romano V, De Leo G, Gennarelli M, Jaruzelska J, Villems R, Parik J, Macaulay V, Torroni A. (2001). Human Y-chromosome variation in the western Mediterranean area: implications for the peopling of the region. Hum Immunol. 62: 871-884.

Shankarkumar U, Prasanavar D, Ghosh K, Mohanty D. (2003). HLA A*02 allele frequencies and B haplotype associations in Western Indians. Human Immunology 64: 562-566.

Shevach EM, Paul WE, Green I. (1972). Histocompatibility linked immune response gene function in guinea pigs. Specific inhibition of antigen induced lymphocyte proliferation by alloantisera. J. Exp. Med. 136: 1213-1229.

Singal DP, Blajchman MA. (1973). Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 22: 429-432.

Slatkin M. (1994). An exact test for neutrality based on the Ewens sampling distribution. Genet. Res. 64: 71-74.

Slatkin M. (1996). A correction to the exact test based on the Ewens sampling distribution. Genet. Res. 68: 259-260.

Smith AG, Matsubara K, Mickelson E, Marashi A, Regen L, Guthrie LA, Hansen JA. (1997). A comparative study of HLA-DRB typing by transcription-mediated amplification with the hybridization protection assay (TMA/HPA) versus PCR/SSOP. Hum Immunol 55: 74-84.

Sollid LM, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. (1989). Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. Journal of Experimental Medicine 169: 345-350.

Sospedra M & Martin R. (2005). Immunology of multiple sclerosis. Annual Review of Immunology 23: 683-747.

Spencer HG & Marks RW. (1988). The maintenance of single locus polymorphism: I. Numerical studies of a viability selection model. Genetics 120: 605–613.

Spínola H, Brehm A, Williams F, Jesus J, Middleton D. (2002). Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route. Ann. Hum. Genet. 66: 285-296.

Spínola H, Middleton D, Brehm A. (2005a). HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa. Tissue Antigens 66: 26-36.

Spínola H, Bruges-Armas J, Middleton D, Brehm A. (2005b). HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing. Human Immunology (in press).

Spínola H, Brehm A, Bettencourt B, Middleton D, Bruges-Armas J. (2005c). HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands. Tissue Antigens 66: 217-230.

Stephens M, Smith NJ, Donnelly P. (2001). A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68: 978-989.

Thorsby E. (1997). Invited Anniversary Review: HLA Associated Diseases. Human Immunology 53: 1-11.

Thorsby E & Lie BA. (2005). HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms. Transplant Immunology 14: 175 – 182.

Tiercy JM, Sanchez-Mazas A, Excoffier L, Shi-Isaac X, Jeannet M, Mach B, Langaney A. (1992). HLA-DR polymorphism in a Senegalese Mandenka population: DNA oligotyping and population genetics of DRB1 specificities. Am. J. Hum. Genet. 51: 592-608.

Tiercy JM. (2002). Molecular basis of HLA polymorphism: implications in clinical transplantation. Transplant Immunology 9: 173-180.

Tosi R, Tanigaki N, Centis D, Ferrara GB, Pressman D. (1978). Immunological dissection of human Ia molecules. J. Exp. Med. 148: 1592-1611.

Tsuneto LT, Probst CM, Hutz MH, Salzano FM, Rodriguez-Delfin LA, Zago MA, Hill K, Hurtado AM, Ribeiro-dos-Santos AKC, Petzl-Erler ML. (2003). HLA class II diversity in seven Amerindian populations. Clues about the origins of the Aché. Tissue Antigens 62: 512-526.

Uko GP, Asuquo MA, Dawkins RL, Udim ER, Banjoko SO, Jaja O. (1997). HLA class I phenotype and gene frequencies in parts of southern Nigeria. Disease Markers 13: 123-130.

Uyar FA, Dorak MT, Saruhan-Direskeneli G. (2004). Human leukocyte antigen -A, -B and –C alleles and human leukocyte antigen haplotypes in Turkey: relationship to other populations. Tissue Antigens 64: 180-187.

Valdes AM, McWeeney SK, Meyer D, Nelson MP, Thomson G. (1999). Locus and population specific evolution in HLA class II genes. Annals of Human Genetics 63:2 7-43.

Van de Wal Y, Kooy YM, Drijfhout JW, Amons R, Koning F. (1996). Peptide binding characteristics of the coeliac disease-associated DQ (alpha1*0501, beta1*0201) molecule. Immunogenetics 44: 246-53.

Van Rood JJ & van Leeuwen A. (1963). Leukocyte grouping. A method and its application. Journal of Clinical Investigation 42: 1382-1390.

Vartdal F, Johansen BH, Friede T, Thorpe CJ, Stevanovic S, Eriksen JE, Sletten K, Thorsby E, Rammensee HG, Sollid LM. (1996). The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule. Eur J Immunol 26: 2764-2772.

Vigilant L. (1999). An Evaluation of Techniques for the Extraction and Amplification of DNA from Naturally Shed Hairs. Biol. Chem. 380: 1329 – 1331.

Walsh SP, Metzger DA, Higuchi R. (1991). Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 10: 506-513.

Watterson G. (1978). The homozygosity test of neutrality. Genetics 88: 405-417.

Weir BS. (1996). Genetic data analysis II. Sunderland: Sinauer Associates. Massachusetts.

Weyand CM, Hicok KC, Conn D, Goronzy JJ. (1992). The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann. Intern. Med. 117: 801-806.

Weyand CM & Goronzy JJ. (2000). Association of MHC and rheumatoid arthritis: HLA polymorphisms in phenotypic variants of rheumatoid arthritis. Arthritis Res. 2: 212–216.

WHO- Nomenclature Committee. (1968). Nomenclature for Factors of the HL-A System. Bull. Wld. Hlth. Org. 39: 483–486.

Williams F, Meenagh A, Maxwell AP, Middleton D. (1999). Allele resolution of HLA-A using oligonucleotide probes in a two stage typing strategy. Tissue Antigens 54: 59-68.

Williams F, Meenagh A, Single R, McNally M, Kelly P, Nelson MP, Meyer D, Lancaster A, Thomson G, Middleton D. (2004). High resolution HLA-DRB1 identification of a Caucasian population. Human Immunology 65: 66-77.

Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L. (2003). Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse. Genome Res. 13: 2621–2636.

Yuhki N, Beck T, Stephens RM, Nishigaki Y, Newmann K, O’Brien SJ. (2003). Comparative Genome Organization of Human,Murine, and Feline MHC Class II Region. Genome Res.13: 1169–1179.

Yunis EJ & Amos DB. (1971). Three closely linked genetic systems relevant to transplantation. Proc. Natl. Acad. Sci. USA 68: 3031-3035.

Zachary AA, Klingman L, Thorne N, Smerglia AR, Teresi GA. (1995). Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity. Transplantation 60: 498-503.